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Overview
Focusing on the needs of the medical oncologist, obstetrician, and gynecologist, this work analyzes the epidemiological, biological, and clinical issues associated with hereditary breast cancer, and offers guidance on the application and utilization of cancer risk assessment models, and screening options for individuals with HBS.
Book details
Format: Hardback
Pages: 384 pages
Height: 254mm
Width: 186mm
Weight: 840g
ISBN: 9780849390227 (0849390222)
Publication date: 19 September 2007
Publisher: Taylor & Francis Ltd
Country of publication: United States
Specialty: Gynaecology & obstetrics, Hereditary diseases & disorders, Oncology
Full details
Practically focusing on the needs of the medical oncologist, obstetrician, and gynecologist, this source analyzes the epidemiological, biological, and clinical issues associated with hereditary breast cancer, and offers clear guidance on the application and utilization of cancer risk assessment models, screening options for individuals with HBS, and the identification of high-risk patients. Addressing every essential aspect of HBC, this source offers succinct analyses of HBC-associated syndromes, low penetrance genes, and mutations of the BRCA 1 and BRCA 2 genes.
Contents
OVERVIEW OF HEREDITARY BREAST CANCER. Genetic Epidemiology of Hereditary Breast Cancer. Risk Estimation Models. HBC SYNDROMES WITH KNOWN GENETIC ETIOLOGIES. Cowden's Syndrome. Li-Fraumeni Syndrome. Other Syndromes that Include Breast Cancer as aComponent. Low Penetrance Genes. ASSESSMENT AND DISSEMINATION OF CLINICAL RISKS FOR BRCA1/2 MUTATION CARRIERS.Biology of BRCA1/2-associated Carcinogenesis. Use of Risk Estimation Models in Clinical Practice. Genetic Testing and Counseling Issues. Mutation Screening: Methods and Limitations.Risk Modifiers. BRCA1/2 in Underserved or Special Populations. Psychological Impact of Testing. SCREENING AND PREVENTION OF HBC IN BRCA1/2 MUTATION CARRIERS.Breast Cancer Screening in High Risk Individuals. Ovarian Cancer Screening in High Risk Individuals. Surgical Prevention of Breast and Ovarian Cancer. Chemoprevention of Breast and Ovarian Cancer. Lifestyle Modification and Other Prevention Approaches.Management of Mutation-negative Women. Synthesis of Screening and Prevention Options. CANCER MANAGEMENT AND OUTCOMES IN BRCA1/2 MUTATION CARRIERS. Pathology in Mutation Carriers. Local treatment issues in HBC. Systemic Treatment Issues. Cancer ManagementIssues in BRCA1/2 Tested Negative Women
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