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Overview
Rather than reviewing work on known antibacterials and antifungals, this identifies new targets - either the rate-limiting component of the pathway that is susceptible to a screening or rational drug design approach - that could lead to the discovery of new classes of drugs.
Book details
Format: Hardback
Pages: 606 pages
Height: 152mm
Width: 230mm
Weight: 1010g
ISBN: 9780412027116 (0412027119)
Publication date: 01 January 1992
Publisher: Kluwer Academic Publishers Group
Country of publication: Netherlands
Specialty: Pharmacology
Full details
This book offers constructive ideas to researchers that could lead to the discovery of entirely new classes of drugs. The authors emphasize new topics rather than review work on known antibacterials and antifungals and identify new targets - either the rate-limiting component of the pathway that is susceptible to a screening or rational drug design approach. Each chapter reviews the biochemical pathway and its place in the cellular scheme in order to place the target in perspective. The authors, a mixture of academic researchers and drug-discovery investigators in pharmaceutical companies, also extend these theoretical concerns into practical applications and suggest useful screening methodologies. The importance of this subject area is demonstrated by the increasing number of papers in the literature that point to potential targets and screening methodologies for new antibacterials. This book also deals with antifungals, investigating the inherent limitations in existing antifungals (many of which are extremely toxic or have only limited efficacy) and pointing to major developments in the discovery of novel antifungals.
This book should be of interest to graduate students in pharmacology, medicine, microbiology, medicinal chemistry; and to industrial and academic scientists in anti-infective research.
Contents
Part 1 Antibacterial chemotherapy: Historical perspectives of approaches to antibiotics discovery, A Imada and K Hotta;
Bacterial pathogens for the 90s - a case for new drug development, G L Drusano;
DNA replication, C S McHenry;
RNA synthesis in bacteria - mechanism and regulation of discrete biochemical events at initiation and termination, A Das, J DeVito, J Sparkowski and F Warren;
Bacterial cell division, J Lutkenhaus;
Fatty acid biosynthesis, S Jackowski;
Protein secretion in bacteria - a chemotherapeutic target?, R Misra and T J Silhavy;
Cytosolic enzymes in peptidoglycan biosynthesis as potential antibacterial targets, W S Faraci;
Strategies in B-lactam design, F Neuhaus and N H Georgopapadakou;
Lipid A biosynthesis, J Coleman;
Compromising the protective barrier of the Gram-negative bacterial cell surface, C P Reese and J Clancy;
Bacterial virulence factors as targets for chemotherapy, S H Highlander and G M Weinstock. Part 2 Antifungal chemotherapy: Invasive fungal infections - problems and challenges for developing new antifungi compounds, T J Walsh;
Topoisomerase II inhibitors - prospects for new antifungal agents, D E Jackson, D P Figgitt and S P Denyer;
Functions for sterols in yeast membranes, L W Parks, R T Lorenz and W M Casey;
Biochemical aspects of ergosterol biosynthesis inhibition, A C Oehlschlager and E Czyzewska;
Chitin synthase as a chemotherapeutic target, N H Georgopapadakou;
Glucan biosynthesis in fungi and its inhibition, J S Tkacz;
Virulence associated mannoproteins in Candida albicans, R A Calderone and M Fukayama;
Screening for antifungal activity, J F Ryley and K J Barrett-Bee;
Chemotherapeutic targets in Pneumocystis carinii, G Y Lipschik and J A Kovacs.
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